I was born in 1965 and graduated from the Faculty of Medicine, The University of Tokyo in 1990. I was initially trained as an orthopaedic surgeon and rheumatologist in the Department of Orthopaedic Surgery, The University of Tokyo. I began my basic research career in 1996 and discovered that bone destruction in arthritis is attributable to the enhanced expression of osteoclast differentiation factor, RANKL, in 2000. I was awarded Ph.D in 2001 and became Assistant Professor at the Department of Immunology, The University of Tokyo. I studied the regulation of bone metabolism by the immune system and explored the interdisciplinary field, osteoimmunology. For the period from 2003 through 2012, I fulfilled responsibilities as a Professor at Tokyo Medical and Dental University. In 2012, I was promoted to Professor, Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo.