Osteocytes and mechanosensory pathways

Osteocytes and mechanosensory pathways

Osteocytes and mechanosensory pathways (#34)

Teresita Bellido ¹

Indiana University School of Medicine, Indianapolis, INDIANAPOLIS, United States

Osteocytes are differentiated osteoblasts embedded in the mineralized bone matrix, which communicate with each other, with osteoblasts and osteoclasts on the bone surface, and with cells of the bone marrow, through the osteocytic lacunar-canalicular network. Osteocytes sense mechanical force imposed to the skeleton and integrate mechanosensory pathways with the action of hormones, thereby leading to the orchestrated response of bone to environmental cues. This presentation will compare and contrast the role of osteocyte-derived sclerostin in bone anabolism induced by mechanical stimulation and PTH administration, and will discuss the potential of osteocytic pathways as therapeutic targets to treat skeletal deterioration.

Authors contributing to this presentation.

Bellido, T

Teresita Bellido, Ph.D., is a graduate of the Universidad Nacional del Sur, Argentina (1988); performed postdoctoral studies at Indiana University, USA (1990-1993); and was a faculty member of the Center for Osteoporosis and Metabolic Bone Diseases and the Division of Endocrinology, Department of Internal Medicine, University of Arkansas for Medical Sciences, USA (1994-2008). She is currently a Professor of Anatomy and Cell Biology and a Professor of Medicine in the Division of Endocrinology, at Indiana University School of Medicine; a member of the Indiana Musculoskeletal Research Center; and a Senior Research Scientist at the Roudebush Medical Center of the Veterans Administration, USA. Dr. Bellido is an expert in signal transduction in bone cells and the regulation of bone cell function by systemic hormones. Her current research focuses on understanding the mechanisms that regulate bone biology and pathophysiology driven by osteocytes.

Osteocytes and mechanosensory pathways (#34)

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Bellido, T

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