Mg-based biometal and hybrid fixation device as an innovative concept to promote fracture healing and its clinical translation — ASN Events
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Mg-based biometal and hybrid fixation device as an innovative concept to promote fracture healing and its clinical translation (#84)

Ling Qin 1
  1. Musculoskeletal Research Laboratory, Dept. of Orthopaedics & Traumatology; Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Sha Tin, Hong Kong

In orthopaedics, Magnesium (Mg) and its alloys are mainly considered suitable for degradable bone implants with good initial stability that avoid a second surgical procedure to remove the temporary metallic parts for fixation after the tissue has sufficiently healed, apart from lowering overall associated health care costs. The author’s group is conducting R&D of orthopaedic implants, in collaboration with biomaterial scientists for developing Mg and its alloys as biodegradable orthopaedic implants and investigating their bone stimulation effects physiologically and biologically using both in vitro and in vivo preclinical experimental models. Human pilot or Phase I studies are also conducted to investigate its biosafety as well as its efficacy for several orthopaedic indications. The presentation generated from this R&D program on Mg or its alloys is based on a translational R&D model and roadmap, with focuses on implant design concept based on observations and novel underlying mechanisms, especially related to local neuronal production of CGRP to improve bone-fracture healing, and then to Proof-of-Concept before clinical trials. Testing standards and guidelines are also essential for this translational roadmap and the author’s group has also been working on necessary modification.

  1. Zhang Y, Xu J, Ruan YC, Yu MK, O'Laughlin M, Wise H, Chen D, Tian L, Shi D, Wang J, Chen S, Feng JQ, Chow DH, Xie X, Zheng L, Huang L, Huang S, Leung K, Lu N, Zhao L, Li H, Zhao D, Guo X, Chan K, Witte F, Chan HC, Zheng Y*, Qin L*. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nat Med. 22(10):1160-1169, 2016
  2. Zhao DW*, Huang SB, FQ Lu, Wang BJ, Yang L, Qin L*, Yang K, Li YD, Li WR, Wang W, Tian SM, Zhang XZ, Gao WB, Wang ZP, Xie XH, Wang JL, Li JL. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head. Biomaterials. 81: 84-92, 2016
  3. Zhao D, Witte F, Lu F, Wang J, Li J, Qin L*. Current status on clinical applications of magnesium-based orthopaedic implants: a review from clinical translational perspective. Biomaterials 112:287-302, 2016
  4. YF Zheng, L Qin, K Yang (eds): Biodegradable Metals (890 pages in Chinese), Sciences Publishing House, Beijing, PR China 2016 (鄭玉峰、秦嶺、楊柯等著：可降解金屬 (共890頁). 科學出版社，2016)
  5. Wang J*, Tang J, Zhang P, Li Y, Wang J, Lai Y, Qin L* Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: A general review.J Biomed Mater Res B Appl Biomater. 100B(6):1691-1701, 2012
  6. Wang JL, Witte F, Xi TF, Zhang YF, Yang K, Yang YS, Zhao DW, Meng J, Li YD, Li WR, Chan KM, Qin L*. Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials. Acta Biomaterialia, 15;21:237-249, 2015
  7. Gu XN, Xie XH, Li N, Zheng YF*, Qin L* In vitro and in vivo studies on a Mg-Sr binary alloy system developed as a new kind of biodegradable metal. Acta Biomaterialia 8(6): 2360-2374, 2012